Blue Light Therapy Benefits 455nm Effect on Skin Cell Nitric Oxide

Main function: Their most crucial role is to form a protective barrier for the body. They produce a tough protein called keratin, which gives skin its strength, integrity, and waterproof properties.

As keratinocytes move from the deeper layers of the epidermis to the surface, they flatten and fill with keratin, eventually forming the stratum corneum (the outermost layer you see and touch).

Origin and migration: They originate in the deepest layer of the epidermis (the stratum basale) and continuously move upwards, differentiating as they go, until they reach the surface and are eventually shed.

Immune function: Beyond being a physical barrier, keratinocytes also play a significant role in the skin’s immune system. They can sense and react to environmental threats, produce various signaling molecules (like cytokines and chemokines) to recruit immune cells, and participate in wound healing.

Relevance to the summary of the Blue Light 455nm Nitric Oxide Study: The summary states that blue light 455nm stimulated Nitric Oxide production in primary keratinocytes (along with fibroblasts). This means that these crucial skin barrier cells were directly affected by the blue light, leading to an increase in nitric oxide, which is a signaling molecule involved in skin health and immune response.

The finding that blue light had a more pronounced effect on NO production in keratinocytes suggests its potential for therapies targeting these cells.